Abstract
Objective: The main purpose of this report is to demonstrate the observation of anterograde Wallerian axonal degeneration (WD) and retrograde neuronal loss to the initial multiple sclerosis (MS) lesion. Material and methods: Longitudinal brain magnetic resonance images (MRI) and single-photon emission computed tomography (SPECT) findings in two relapsing-remitting multiple sclerosis (RR MS) patients are shown. Conclusion: This is an unusual report of long-standing asymptomatic bidirectional progression of the initial lesion. Our data suggest that axonal and neuronal neurodegeneration may occur in the absence of symptoms.
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