Abstract
Background: Metastatic anal Squamous Cell Carcinoma (SCC) is a relatively uncommon malignancy that is usually treated with palliative platinum based chemotherapy. Response rates are modest and complete responses are rare. Case Report: Here we report on a case of advanced SCC with the extensive visceral metastatic disease that has possibly been cured with chemotherapy alone. The patient has received 6 cycles of Cisplatin and 5FU and has remained in complete remission for over 7 years. Conclusion: This is the first report of a case of metastatic anal SCC that has been cured with chemotherapy and highlights the need to remain optimistic when treating patients with “palliative” chemotherapy.
Highlights
Metastatic anal Squamous Cell Carcinoma (SCC) is a relatively uncommon malignancy that is usually treated with palliative platinum based chemotherapy
There is a close association between Human Papilloma Virus (HPV) infection and anal squamous cell carcinoma, with HIV infection well recognized to increase the risk of developing anal SCC
The patient remains in ongoing complete clinical and radiological remission (Figure 1(b)). This case report illustrates a complete response to cisplatin/infusional 5FU chemotherapy despite widespread metastatic disease including very extensive liver involvement, and sustained and ongoing complete remission, beyond seven years of follow-up
Summary
Anal cancer is rare, representing
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