Abstract
In the molecular biology equivalent of stubbing one's toe on King Tut's undiscovered tomb, a team of scientists, to its great surprise, has identified a genetic switch hunted by biologists for decades. The switch, buried deep inside a cell's nucleus, is an enzyme that chemically alters the protein spools around which a cell's DNA wraps. The enzyme's discovery, reported online last week in Cell and in the 29 December issue—along with related finds published this fall—has scientists racing to find more switches like it. The switches could reveal much about how cells control gene activity and illuminate cancer, multiple sclerosis, and other diseases that may be spurred by gene expression gone awry.
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