Abstract
The objective of this study was to examine the relationship between sleep duration and ischemic and hemorrhagic stroke in a community-based cohort. The current analysis included 95,023 Chinese participants who were free of stroke at the baseline survey (2006–2007). Cox proportional hazards models were used to calculate hazard ratios (HRs) and their confidence intervals (CIs) for stroke, according to sleep duration. After a mean follow-up period of 7.9 years, 3,135 participants developed stroke (2,504 ischemic stroke and 631 hemorrhagic stroke). The full adjusted hazard ratio (95% CI) of total stroke (with 6–8 hours of night sleep being considered for the reference group) for individuals reporting greater than 8 hours was 1.29 (1.01–1.64). More significant association between long sleep duration and total stroke was found in the elderly (HR, 1.47; 95% CI, 1.05–2.07). Compared with participants getting 6–8 hours of sleep, only women who reported sleeping more than 8 hours per night were associated with hemorrhagic stroke (HR, 3.58; 95% CI, 1.28–10.06). This study suggested that long sleep duration might be a potential predictor/ marker for total stroke, especially in the elderly. And long sleep duration increased the risk of hemorrhagic stroke only in women.
Highlights
Evidence is mixed and inconsistent regarding this association between sleep duration and risk of stroke
Significant associations were found among sleep duration and age, sex, education level, income level, smoking status, drinking status, physical activity, family history of stroke, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, hypotensive drug use, lipid-lowering drug use, hypoglycemic drug use, history of myocardial infarction, snoring status, high sensitive C-reactive protein, and atrial fibrillation
Analysis of the full adjusted data using model 4 indicated that participants in the >8 h group were more likely to develop stroke than those in the 6–8 h group (HR, 1.29; 95% confidence intervals (CIs), 1.01–1.64)
Summary
Evidence is mixed and inconsistent regarding this association between sleep duration and risk of stroke. Some studies have suggested that only long sleep duration (≥10 h or >8 h/d)[3,5,6,7] is associated with an increased risk of stroke, while others indicate only short sleep duration (
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