Abstract
Elongation factor Tu (EF‐Tu) is a GTPase that delivers aminoacyl‐tRNA (aa‐tRNA) to the ribosome during protein synthesis. The factor is activated in response to the correct recognition of the mRNA codon by the anticodon of the aa‐tRNA. The mechanism of signalling between the decoding centre of the ribosome and the site of GTP hydrolysis in EF‐Tu where GTP hydrolysis takes place is not known. New high‐resolution cryo‐electron microscopic (cryo‐EM) structures of the ribosome complex with aa‐tRNA and EF‐Tu blocked by the antibiotic kirromycin provide insights into the mechanistic details of the long‐range signalling responsible for GTPase activation.
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