Abstract
In addition to protein-coding genes, the human genome makes a large amount of noncoding RNAs. Long non-coding RNAs (lncRNAs) have been described as the largest subclass of the non-coding transcriptome in human noncoding RNAs. In recent years, lncRNAs have been considered to be the key regulators of tumor behavior. In this study, based on previous research, we investigated the expression and biological role of a newly identified cancer-related lncRNA, lncRNA-uc002kmd.1. We analyzed the relationship between lncRNA-uc002kmd.1 and colorectal cancer (CRC) in a total 45 CRC and paired adjacent, non-tumor tissue samples. We found that lncRNA-uc002kmd.1 expression was usually highly expressed in carcinoma compared with the tissue adjacent to the carcinoma. Through a series of experiments, the results showed that lncRNA-uc002kmd.1 regulates CD44 as a molecular decoy for miR211-3p. Our data indicated that the overexpression of lncRNA-uc002kmd.1 enhanced cell proliferation in CRC.
Highlights
Colorectal cancer (CRC) is an important public health problem globally and remains a major cause of cancer mortality in the developed world, largely due to its propensity to metastasize [1]
We identified the Long non-coding RNAs (lncRNAs)-uc002kmd.1 in CRC and found that it was dramatically up-regulated in CRC tissue using the reverse transcriptase polymerase chain reaction assay, indicating the potential function of lncRNA-uc002kmd.1 in CRC
A series of experiments have illustrated the correlation between lncRNA-uc002kmd.1, miR-211-3p and CD44, concluding that lncRNA-uc002kmd.1 regulates CD44-dependent cell growth by competing for miR-211-3p in colorectal cancer
Summary
Colorectal cancer (CRC) is an important public health problem globally and remains a major cause of cancer mortality in the developed world, largely due to its propensity to metastasize [1]. It is the second most common cancer diagnosis among women and the third most common among men[2]. The achievements in colorectal cancer research are remarkable, new and effective therapeutic strategies are still needed. The search for new biomarkers for metastatic progression in colorectal cancer is urgent. Long non-coding RNAs (lncRNAs), which comprise non-coding transcripts of more than 200 nucleotides, have been described as the largest subclass of the non-coding transcriptome in PLOS ONE | DOI:10.1371/journal.pone.0151287. Long non-coding RNAs (lncRNAs), which comprise non-coding transcripts of more than 200 nucleotides, have been described as the largest subclass of the non-coding transcriptome in PLOS ONE | DOI:10.1371/journal.pone.0151287 March 14, 2016
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