Long noncoding RNA MALAT1 acts as a potential biomarker in cancer diagnosis and detection: a meta-analysis.

Abstract

it has been reported that metastasis-associated lung adenocarcinoma transcript 1 is abnormally expressed in various cancers. eligible studies fulfilling the search criteria were selected from the online databases. Statistical analysis was performed based on the platforms of STATA 14.0. 12studies were included in this study comprising 741 cases and 794 controls. The pooled results were shown as follows: sensitivity, 0.74 (95%CI: 0.64-0.82), specificity, 0.83 (95% CI: 0.75-0.88), positive likelihood ratio (PLR), 4.2 (95% CI: 3.00-5.90), negative likelihood, 0.32 (95% CI: 0.23-0.43), diagnostic odds ratio, 13 (95%CI: 8.00-21.00) and area under the curve, 0.85 (95%CI: 0.82-0.88). Deeks' funnel plot asymmetry test (p=0.70) suggested no potential publication bias. long noncoding RNA Metastasis-associated lung adenocarcinoma transcript 1 might be a usable biomarker for cancer diagnosis and detection.