Abstract
The mitotic serine/threonine kinase aurora kinase-A (AURKA) has been identified as carcinogenic in hepatocellular carcinoma (HCC). AURKAPS1, a long non-coding RNA (lncRNA), is the pseudo-gene of AURKA, which play important roles in the cancer. Its underlying functions and mechanisms in liver cancer progression remain largely unknown. The mRNA expression of AURKAPS1 in HCC tumor tissues was significantly higher, which is associated with tumor size and TNM stage. The high expression of AURKAPS1 promotes cell movement, migration and invasion. AURKAPS1 can increases the protein expression of RAC1, promotes the activation of ERK, and enhance the formation of membrane ruffles by binding with miR-182, miR-155 and miR-142 competively. Thus, AURKAPS1 could be a useful marker, and the combination of AURKAPS1/miRNAs (miR-142, miR-155 and miR-182) may be a new theoretical basis for the treatment of HCC.
Highlights
Hepatocellular carcinoma (HCC) is a lethal cancer with increasing frequency in the world in the recently decades
AURKAPS1 expression in 124 cases liver cancer tissues was detected by quantitative real-time PCR, and the results showed that AURKAPS1 expression was significantly higher in hepatocellular carcinoma (HCC) tissues than in adjacent normal liver tissues (Fig. 1C)
The expression level of AURKAPS1 was positively correlated with tumour size and TNM stage (Fig. 1D,E), but not with sex, age, history of hepatitis, or lymph node metastasis (Table 1), suggesting that AURKAPS1 may be associated with tumour invasion and metastasis
Summary
Hepatocellular carcinoma (HCC) is a lethal cancer with increasing frequency in the world in the recently decades. LncRNAs can modulate the functions of target microRNAs (miRNAs) by acting as a competitive endogenous RNA (ceRNA)[15]. The expression and functions of AURKAPS1 in tumours have not been reported. LncRNAs can function as a ceRNA or as a molecular sponge to modulate the expression and biological functions of miRNA, for example, via regulating the post-transcriptional proceed. Whether AURKAPS1 affects tumourigenesis by regulating miRNAs remains unclear. In this project, we found the expression of AURKAPS1 was significantly higher in HCC tissues and cell lines, AURKAPS1 potentiates the invasion and metastasis of HCC cells by regulating miRNAs, so it may become a potential target for the treatment of HCC in the future
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