Long noncoding RNA and its role in the development and metastasis of hypopharyngeal squamous cell carcinoma

Abstract

Objective To elaborate the important role of long noncoding RNA (LncRNA) in the regulation of tumor development and hypopharyngeal squamous cell carcinoma (HSCC). Methods Related publications with长链非编码RNA,下咽癌/下咽鳞状细胞癌β-连环蛋白,下咽癌/下咽鳞状细胞癌andLncRNAs, tumorLncRNAs, HSCCWnt/β-catenin , EMTβ-catenin, HSCCwere searched, analyzed and summarized in the database of CNKI, Wanfang Data, PubMed, Google academic, EMBASE database from January 2000 to September 2018 to review the role and molecular mechanism of LncRNAs in the development of HSCC. The mechanism of LncRNAs and Wnt pathway in the development of HSCC were reviewed. Altogether 3 297 related publications were searched and finally 48 papers were included according to the inclusion and exclusion criteria, containing 2 Chinese papers and 46 English papers. Results LncRNA were widely involved in the repair of DNA damage and physiological or pathological processes such as apoptosis, and plays an important role in the process of biological regulation. Wnt signaling pathway is an important cell signal transduction pathway, which plays an important role in cell proliferation and differentiation. The combination of LncRNAs and mRNA promoted the occurrence and development of HSCC. LncRNA promotes HSCC metastasis and recurrence through Wnt signaling pathway. Conclusions LncRNA are closely related to the pathogenesis of many disease, such as tumorigenesis. The occurrence and development of HSCC is regulated by LncRNA, and LncRNA plays an important role in the growth migration and invasion of HSCC tumor cells through Wnt signaling pathway. Key words: RNA; Hypopharyngeal neoplasms; Long noncoding RNA; Hypopharyngeal squamous cell carcinoma; Wnt signaling pathway; E-cadherin; β-catenin