Abstract
OBJECTIVES:To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the ten-eleven translocation enzyme 1 (TET1) transcriptional expression in postoperative recurrence of uterine fibroids (UFs).METHODS:Seventy-five patients with UF, who underwent surgical treatment, were enrolled in the treatment group, and 60 healthy individuals were enrolled in the control group. The relative expression levels of lncRNA H19 and TET1 mRNA in the serum and UF tissues were analyzed. The patients were further divided into a better curative (BC) group and a poor efficacy (PE) group to analyze the predictive value of lncRNA H19 and TET1 and the independent risk factors affecting the recurrence of UF.RESULTS:Compared with the control group, lncRNA H19 expression levels were significantly higher, while TET1 expression levels were significantly lower in the treatment group (p<0.001). The area under the receiver operating characteristic (ROC) curve (AUC) values of the two indicators for diagnostic importance were found to be 0.872 and 0.826, respectively. Compared with the PE group, lncRNA H19 expression levels were significantly lower, while TET1 expression levels were significantly higher in the BC group (p<0.001). The AUC values of the two indicators for their predictive efficacy were 0.788 and 0.812, respectively. Logistic regression analysis showed that age, menarche age, maximum diameter of UFs, number of UFs, lncRNA H19 levels, and TET1 levels were independent risk factors affecting UF recurrence. The AUC values of lncRNA H19 and TET1 for their predictive value for postoperative recurrence were 0.814 and 0.765, respectively.CONCLUSIONS:The lncRNA H19 and TET1 have high diagnostic and predictive efficacy for determining the postoperative recurrence of UFs.
Highlights
Uterine fibroids (UFs) are benign uterine smooth muscle tumors that affect the fertility of women of childbearing age
UFs are mainly diagnosed using imaging in clinical practice [28]. long non-coding RNA (lncRNA) H19 and teneleven translocation enzyme 1 (TET1) are considered important regulatory factors in the pathogenesis of UFs, but their diagnostic value remains unclear
The area under the curve (AUC) of the receiver operating characteristic (ROC) curves for lncRNA H19 and TET1 were 0.872 and 0.826, respectively, suggesting that these two factors are valuable in diagnosing UFs
Summary
Uterine fibroids (UFs) are benign uterine smooth muscle tumors that affect the fertility of women of childbearing age. The incidence of UFs varies with age, with 40–80% of women of childbearing age being diagnosed with this disease [1]. Patients with UF may be asymptomatic or show severe and chronic symptoms, of which the most common ones include. No potential conflict of interest was reported. Received for publication on August 10, 2021. Accepted for publication on August 16, 2021
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