Abstract
BackgroundSmall nucleolar RNA host gene 17 (SNHG17), a novel cancer-related long noncoding RNA (lncRNA), was reported to be responsible for processing and developing in several cancers. Nonetheless, the clinical significance and biological function of SNHG17 in human breast cancer (BC) remain rarely known.Materials and methods58 pairs of BC tissues and adjacent non-cancerous tissues were harvested to measure SNHG17 expression levels. SNHG17 was knockdown to study its biological behavior in BC cells. The microRNAs (miRNAs) that can bind to SNHG17 were predicated using Starbase2.0 and were tested using luciferase reporter activity and RIP assays. A xenograft model was established to investigate the impact of SNHG17 in tumor growth in vivo.ResultsAn increased SNHG17 was observed in BC samples and cell lines compared with corresponding control. Increased SNHG17 was closely associated with poor prognosis.SNHG17 depletion suppressed cell proliferation, migration and invasion in vitro, as well as inhibited tumor growth in xenograft tumor models. Mechanistically, SNHG17 could function as an endogenous sponge of miR-124-3p in BC cells. Moreover, the repression of cell proliferation, migration and invasion induced by SNHG17 knockdown would reversed by miR-124-3p inhibitor.ConclusionThe present study demonstrated that the lncRNASNHG17 could regulate the progression of BC by sponging miR-124-3p.
Highlights
Small nucleolar RNA host gene 17 (SNHG17), a novel cancer-related long noncoding RNA, was reported to be responsible for processing and developing in several cancers
Increased SNHG17 was closely associated with poor prognosis.SNHG17 depletion suppressed cell proliferation, migration and invasion in vitro, as well as inhibited tumor growth in xenograft tumor models
The present study demonstrated that the lncRNASNHG17 could regulate the progression of breast cancer (BC) by sponging miR-124-3p
Summary
Small nucleolar RNA host gene 17 (SNHG17), a novel cancer-related long noncoding RNA (lncRNA), was reported to be responsible for processing and developing in several cancers. The ncRNAs includes long noncoding RNAs (lncRNAs, a type of ncRNAs over 200 nucleotides in length and with limited protein-coding ability) [6], and microRNAs that inhibit target gene expression by binding to the 3′ UTR (3′ untranslated region) of a target gene [7]. Both lncRNAs and miRNAs were shown to be involved in the regulation of the initiation and development of various cancers including BC [8, 9]. A body of evidence demonstrated that lncRNAs could serve as competing endogenous RNAs (ceRNAs)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
