Abstract
A large number of human RNA transcripts, which do not encode proteins are defined as non-coding RNAs (ncRNAs). These ncRNAs are divided into two classes of different lengths; short and long ncRNAs. MicroRNAs are a major class of short ncRNAs, ~22 nucleotides in length that regulate gene expression at the post-transcriptional level. Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and play roles in various biological pathways. In this review, we summarize the functions of lncRNAs which regulate immune responses.
Highlights
Whole transcriptome analyses of mammalian genomes, such as studies documented in the ENCODE project, have characterized RNA transcripts that have low-protein coding potential, known as non-coding RNAs [1]
We summarize the functions of long non-coding RNAs (lncRNAs) which regulate immune responses
NcRNAs are classified into short ncRNAs and long non-coding RNAs [6]
Summary
Reviewed by: Paul Quax, Leiden University Medical Center, Netherlands Peter L. Commonwealth Scientific and Industrial Research Organisation, Australia Maninjay K. A large number of human RNA transcripts, which do not encode proteins are defined as non-coding RNAs (ncRNAs).These ncRNAs are divided into two classes of different lengths; short and long ncRNAs. MicroRNAs are a major class of short ncRNAs, ~22 nucleotides in length that regulate gene expression at the post-transcriptional level. Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and play roles in various biological pathways. We summarize the functions of lncRNAs which regulate immune responses
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