Long non-coding RNAs in osteosarcoma.

Ruiling Chen,Zhengdong Cai,Gangyang Wang,Yingqi Hua,Ying Zheng

doi:10.18632/oncotarget.14726

Abstract

Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored to participate in various cancer types including osteosarcoma (OS), which is the most common kind of primary bone tumors with high morbidity in infants and adolescents. These oncogenic or tumor suppressive lncRNAs regulate OS pathogenesis, such as cell growth, proliferation, invasion, migration, metastasis and cell apoptosis, serve as independent prognostic biomarkers or play a significant role in multidrug resistance (MDR) in OS cells. In this review, we attempt to dissect the participation of lncRNAs in pathogenesis of OS and their potential clinical values, and also provide an outlook for viable biomarkers and therapeutic targets in OS.

Highlights

Osteosarcoma(OS) is the most common primary malignant bone tumor in childhood and adolescence, the incidence of which is about (1-3)/1000, 000 per year throughout the world, with highly aggressive and early systemic metastasis [1,2,3,4]
Overexpressed HOTAIR in OS tumor tissues that markedly promotes tumor growth and metastasis [62], increased MALAT1 with involvement of signaling pathways and miRNA [54,55,56], down-regulated long non-coding RNAs (lncRNAs) TUSC7 associated with cell proliferation [43], elevated BCAR4 related to lung metastasis by regulating GLI2-dependent gene [80], and independent prognostic predictor BANCR [86] imply the possiblity of targeted therapy based on lncRNAs
This review summarizes results from recent studies of lncRNAs that act as oncogenes by overexpression or tumor suppressors by downexpression in OS, like HOTAIR, MALAT1, H19, TUG1, MEG3 and TUSC7

Summary

Introduction

Osteosarcoma(OS) is the most common primary malignant bone tumor in childhood and adolescence, the incidence of which is about (1-3)/1000, 000 per year throughout the world, with highly aggressive and early systemic metastasis [1,2,3,4]. Peiheng He et al revealed that overexpression of tumor suppressor miR-141 inhibited osteoblastic cell proliferation through down-regulation of H19 or miR-675 in OS [61], which illustrates the interaction of endogenous miRNAs with lncRNAs. HOTAIR (HOX transcript antisense RNA, HOTAIR), a 2337nt lncRNA located at 12q13.13, has a high expression in OS tumor tissues, and notably promotes tumor growth [62].

Results

Conclusion