Abstract
Intrinsic resistance to ionizing radiation is the major impediment in the treatment and clinical management of esophageal squamous cell carcinoma (ESCC), leading to tumor relapse and poor prognosis. Although several biological and molecular mechanisms are responsible for resistance to radiotherapy in ESCC, the molecule(s) involved in predicting radiotherapy response and prognosis are still lacking, thus requiring a detailed understanding. Recent studies have demonstrated an imperative correlation amongst several long non-coding RNAs and their involvement in complex cellular networks like DNA damage and repair, cell cycle, apoptosis, proliferation, and epithelial-mesenchymal transition. Additionally, accumulating evidence has suggested abnormal expression of lncRNAs in malignant tumor cells before and after radiotherapy effects in tumor cells’ sensitivity. Thus, lncRNAs indeed represent unique molecules that can influence tumor cell susceptibility for various clinical interventions. On this note, herein, we have summarized the current status of lncRNAs in augmenting resistance/sensitivity in ESCC against radiotherapy. In addition, we have also discussed various strategies to increase the radiosensitivity in ESCC cells under clinical settings.
Highlights
Esophageal cancer (EC) is one of the most lethal cancer types and is the eighth most common cancer [1]
We summarize the current scientific insights into the association of long non-coding RNAs (lncRNAs) with a response to radiotherapy and a predictive biomarker for radiation treatment in Esophageal squamous cell carcinoma (ESCC) patients
We observed that lncRNAs might act as potential therapeutic targets because of their differential expression patterns in ESCC cancerous tissue/cell lines before and after radiation therapy
Summary
Esophageal cancer (EC) is one of the most lethal cancer types and is the eighth most common cancer [1]. Recent studies have reported the association of long non-coding RNAs (lncRNAs) with altered patients’ responses towards radiation therapy due to their active involvement in DNA damage response (DDR), apoptosis, and cell cycle arrest [11,12]. With this idea, we have collated scientific literature correlating several dysregulated lncRNAs corresponding to ESCC diagnostic when exposed to radiation therapy. TE-1 ~6.2-folds EC9706 ~6.8-folds ECA109 ~3.6-folds KYSE-450 ~1.6-folds Tissues- ~2.6-folds
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