Abstract
Increasing evidences showed that long non-coding RNAs (lncRNAs) play vital roles in tumor progression. Recent studies indicated that lncRNA TUG1 was upregulated and promoted tumor processes in several cancers. However, the expression and underlying mechanism of TUG1 in cervical cancer remain unclear. In the present study, we found that TUG1 expression was upregulated in cervical cancer tissues and correlated with advanced clinical features and poor overall survival. TUG1 knockdown suppressed cervical cancer cell growth and metastasis in vitro and tumor growth in vivo. In addition, our results indicated that TUG1 could act as an endogenous sponge by directly binding to miR-138-5p and suppressed miR-138-5p expression. Furthermore, we found that TUG1 could reverse the inhibitory effect of miR-138-5p on cervical cancer cells processes, which might be involved in the activation of SIRT1, a target gene of miR-138-5p, and activation of Wnt/β-catenin signaling pathway. Taken together, we elucidated that TUG1 might promote cervical cancer malignant progression via miR-138-5p-SIRT1-Wnt/β-catenin signaling pathway axis.
Highlights
Cervical cancer (CC) is the third most common cancer in women globally [1]
We found that Taurine up-regulated 1 (TUG1) could reverse the inhibitory effect of miR-138-5p on cervical cancer cells processes, which might be involved in the activation of SIRT1, a target gene of miR-138-5p, and activation of Wnt/β-catenin signaling pathway
LncRNA TUG1 expression levels are elevated in CC
Summary
Cervical cancer (CC) is the third most common cancer in women globally [1]. Various treatments such as surgery, chemotherapy and radiotherapy have been used for the treatment of CC, the prognosis is still poor with a 5-year survival rate of approximately 40% [2, 3]. Li et al found that lncRNA HOTTIP overexpression could increase chemoresistance of osteosarcoma cell via activation of the Wnt/β-catenin signaling [9]. Those studies suggested that lncRNAs could exert critical functions in tumor development and progression. The functions and underlying molecular mechanisms of lncRNAs in tumor progression remain largely unknown
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