Abstract
In recent years, many studies have reported on the abnormal expression and correlation of long non-coding RNAs (lncRNAs) in tumours. However, the accurate molecular mechanism of lncRNAs in glioma is still in its infancy. In the present study, we aimed to explore the molecular mechanism of small nucleolar RNA host gene 5 (SNHG5) in glioma progression. First, we found that SNHG5 expression was higher in glioma and was related to glioma glucose uptake, migration and invasion. Second, through a series of assays, we concluded that SNHG5 acts as a sponge for miR-205, which inhibits tumour growth in glioma by targeting E2F transcription factor 3 (E2F3). Third, using a xenograft mouse model, we demonstrated that SNHG5 regulates tumourigenesis in vivo. Taken together, our results show that the SNHG5/miR-205/E2F3 axis is involved in glioma progression and may provide a new therapeutic target for the diagnosis and therapy of glioma.
Highlights
Glioma accounts for 70% of adult primary pernicious brain tumours [1,2,3]
The results indicated that compared with normal tissues, the expression level of small nucleolar RNA host gene 5 (SNHG5) is significantly increased in gliomas (Figure 1B)
Many studies have revealed the function of Long non-coding RNAs (lncRNAs) in various human tumours, which has increased our understanding of the molecular mechanism of tumourigenesis [21,22,23]
Summary
Glioblastoma multiforme (GBM) is the most aggressive and malignant type of glioma, with a poor prognosis and high mortality due to the highly proliferative and invasive nature of the tumour [4,5]. It is critical to expound the molecular mechanisms underlying glioma progression and design reasonable therapeutic interventions for the early diagnosis and treatment of this disease. Long non-coding RNAs (lncRNAs), a set of non-coding RNAs (ncRNAs) with a length of more than 200 nucleotides, make a significant contribution in cancer biology and serve as biomarkers and therapeutic targets for many human neoplastic diseases [6,7,8]. Comprehending the role of cancer-related lncRNAs to uncover new insights about the mechanisms of tumour progression is of far-reaching significance
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