Abstract
Long non-coding RNA (lncRNA) SNHG14 is previously found to be overexpressed in several types of cancers. However, the clinical significance and biological function of SNHG14 in non-small cell lung cancer (NSCLC) are still elusive. In the present study, we found that SNHG14 was aberrantly up-regulated in NSCLC tissues from patients and cell lines compared with their normal counterparts. Increased SNHG14 expression was closely associated with aggressive tumor progression and poor clinical outcome of NSCLC patients. Knockdown of SNHG14 inhibited NSCLC cell proliferation through inducing cell cycle arrest and apoptosis, whereas SNHG14 overexpression exerted the opposite effects. Animal experiment further revealed that down-regulated SNHG14 greatly inhibited NSCLC tumor growth in vivo. Further studies demonstrated that SNHG14 might serve as a competing endogenous RNA (ceRNA) by sponging miR-340 in NSCLC cells. Taken together, our study demonstrated that SNHG14/miR-340 axis might play a novel role in regulating the malignant behaviors of NSCLC, which provided a new potential diagnostic and therapeutic strategy for this malignant disease.
Highlights
Lung cancer is the leading cause of cancer-related deaths worldwide, which is a serious threat to human health [1]
We examined the correlation between Small nucleolar RNA host gene 14 (SNHG14) expression and the clinicopathologic characteristics of 99 non-small cell lung cancer (NSCLC) patients
We examined the expression of SNHG14 in a number of NSCLC cell lines, and observed that increased SNHG14 expression could be observed in all four NSCLC cell lines, compared with normal 16HBE cells (Figure 1C)
Summary
Lung cancer is the leading cause of cancer-related deaths worldwide, which is a serious threat to human health [1]. It is of great importance to explain the molecular mechanisms underlying the initiation and progression of NSCLC, and identify novel therapeutic targets to improve the efficacy of clinical anti-NSCLC management. The human genome expresses tens of thousands of long non-coding RNAs (lncRNAs), which are a type of RNA molecules greater than 200 nts in length with little protein-coding potential [4,5]. Recent studies revealed that lncRNAs can function as an oncogene or tumor suppressor in a variety of cancer types, including NSCLC [6,7]. In this regard, highlighting the potentially widespread functional roles of lncRNAs in NSCLC is of critical importance
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