Abstract
A previous study implied that long intergenic non-coding RNA 1410 (LINC01410) promotes angiogenesis and metastasis of gastric cancer. However, the role of LINC01410 in colon cancer (CC) has remained elusive. In the present study, LINC01410 was identified to be highly expressed in CC tissues compared to adjacent normal tissues. It was indicated that high expression of LINC01410 in CC tissues was associated with poor prognosis. Further functional study suggested that LINC01410 knockdown significantly reduced the proliferation and invasive capacity of HT-29 and SW620 cells, and inhibited the cell cycle. Regarding the mechanism, LINC01410 was indicated to serve as a sponge for microRNA (miR)-3128, as evidenced by a luciferase reporter assay. Furthermore, knockdown of LINC01410 significantly increased the levels of miR-3128. In addition, miR-3128 was markedly downregulated in CC tissues compared with that in adjacent normal tissues. A rescue assay revealed that inhibition of miR-3128 significantly abrogated the effects of LINC01410 knockdown on CC cell proliferation and invasion. In conclusion, the present study demonstrated that LINC01410 functions as an oncogene in CC, at least in part by directly inhibiting miR-3128.
Highlights
Colon cancer (CC) is the third most common cancer type and the fourth leading cause of cancer‐associated mortality worldwide [1]
The results indicated that LINC01410 expression was significantly upregulated in CC tissues compared with that in adjacent normal tissues (Fig. 1A)
MiR‐3128 was identified as a direct target of LINC01410 and it was demonstrated that the inhibition of proliferation and invasion by LINC01410 knockdown was abrogated by miR‐3128 inhibitors
Summary
Colon cancer (CC) is the third most common cancer type and the fourth leading cause of cancer‐associated mortality worldwide [1]. The 5‐year survival rate of CC patients remains unsatisfactory [3]. Liver or lung metastasis is frequent in CC patients, and is one of the major causes of CC‐associated. LncRNAs have a length of >200 nucleotides and do not encode any protein [6]. Accumulating evidence suggests that lncRNAs possess key functions in multiple biological processes, including cell development, migration and propagation [7,8]. Various lncRNAs are aberrantly expressed in cancer and their levels are correlated with the clinicopathological characteristics of the patients. LncRNA UICLM increases CC metastasis via the sequester of microRNA (miR)‐215 to promote Zinc finger E‐Box binding homeobox 2 expression [11]. Most lncRNAs remain to be identified and functionally validated
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