Abstract
Long non-coding RNAs (lncRNAs) are a group of transcripts over 200 nucleotides in length that do not code for proteins. The association of the dysregulation of numerous lncRNAs with several malignancies, including lung cancer, has been frequently reported. This study aims to inspect the association of genomic and transcriptomic alterations to the lncRNA LINC00987 with lung adenocarcinoma, a subtype of lung cancer, using a bioinformatic approach. To this end, we used three publically available online databases, cBioPortal, the International Cancer Genome Consortium Data Portal and the GEPIA web server. In short, our results demonstrated that LINC00987 expression might have a tumor suppressive role in lung adenocarcinoma and levels of expression could be of prognostic value for this cancer type.
Highlights
Lung cancer is the leading cause of cancer-related death in the world among both men and women[1]
The mutations to LINC00987 Long non-coding RNAs (lncRNAs) in Lung adenocarcinoma (LUAD) was analyzed by means of the International Cancer Genome Consortium (ICGC) Data Portal To this purpose, the “LINC00987” term was searched in the ICGC Data Portal and the projects related to the LUAD were selected from the results
The aim of this study was to examine the association of genotranscriptomic alterations of LINC00987 lncRNA with LUAD using a bioinformatic approach
Summary
Lung cancer is the leading cause of cancer-related death in the world among both men and women[1]. Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and accounts for over a million cancer-related deaths each year[2,3]. Long non-coding RNAs (lncRNAs) are a subclass of non-protein-coding transcripts over 200 nucleotides in length that are involved in several cancer-related biological processes, including cell growth, cell proliferation, and apoptosis[4,5]. It has been frequently reported that lncRNAs, due to their pivotal regulatory roles in the cellular events, especially cell cycle processes, can be used as cancer biomarkers[6]. The genomic and transcriptomic alterations to LINC00987 lncRNA in LUAD have not yet been precisely examined
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