Abstract
Gastric cancer (GC) is a considerable global health burden. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and play important roles in GC. However, only a few lncRNAs have been functionally characterized. In this study, we identified that long intergenic non-protein coding RNA 941 (LINC00941) is a potential biomarker for diagnosis and prognosis from the cancer genome atlas (TCGA), and we found that the expression of LINC00941 is associated with tumor depth and distant metastasis in GC. Furthermore, functional enrichment analysis of LINC00941 co-expression network demonstrated that LINC00941 might be an essential regulator of tumor metastasis and cancer cell proliferation. To validate our findings, we utilized the loss-of-function analysis to reveal the biological function of LINC00941 in GC cells. Loss-of-function analysis revealed that silence of LINC00941 inhibits GC cells proliferation, migration, and invasion in vitro and modulates tumor growth in vivo. Our findings confirmed that LINC00941 plays an important oncogenic function in GC and may serve as a potential biomarker for diagnosis and prognosis of GC.
Highlights
Gastric cancer (GC) is one of the most frequently diagnosed cancer and the leading cause of cancer death in the world (Bray et al, 2018)
We identified that LINC00941 acts as a potential diagnostic and prognostic biomarker in GC, and the expression of LINC00941 is associated with tumor depth and distant metastasis based on the analysis of RNA-seq data from the cancer genome atlas (TCGA)
Our findings indicated that LINC00941 is a potential biomarker for diagnosis and prognosis of GC
Summary
Gastric cancer (GC) is one of the most frequently diagnosed cancer and the leading cause of cancer death in the world (Bray et al, 2018). The outlook for patients with metastatic GC is unfavorable, with median survival does usually not exceed 1 year (Van Cutsem et al, 2016). Long non-coding RNAs (lncRNAs) is an important subclass of non-coding RNAs (ncRNAs) and usually longer than 200 nucleotides with lack of protein-coding capability (Engreitz et al, 2016). Mounting evidence confirmed that lncRNAs are aberrantly expressed in many cancers and play key roles in promoting tumor initiation and progression (Lin and Yang, 2018). Several lncRNAs such as UCA1, MALAT1, HOXA11-AS, and ZEB1-AS1 have been proposed as individual diagnostic or LINC00941 Is a Cancer Biomarker prognostic biomarkers in GC (Sun et al, 2016; Li et al, 2017a,b; Wang et al, 2017). Only a few lncRNAs have been functionally characterized and the mechanism by which lncRNAs regulate GC remains to be fully elucidated
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