Abstract
Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until August 14, 2016 and identified seven studies with 730 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between HULC expression and overall survival (OS). We also using RevMan5.3 software to calculate odds ratio (ORs) to assess the association between HULC expression and pathological parameters, including lymph node metastasis (LNM), distant metastasis (DM) and the tumor stage. Our analysis showed that higher HULC expression was associated with OS (HR= 0.50, 95% CI: 0.35–0.70, P <0.00001), LNM (OR=0.20, 95 % CI 0.06–0.64), DM (OR=0.27, 95% CI: 0.13–0.54) and the tumor stage (OR=0.39, 95 % CI 0.25–0.64). These meta-analysis data demonstrate that higher HULC expression can be a useful prognostic biomarker in human cancers.
Highlights
In 2012, nearly 8.2 million people reportedly died from cancer and about 14.1 million people were diagnosed with cancer worldwide [1]
Our analysis showed that higher HULC expression was associated with overall survival (OS) (HR= 0.50, 95% confidence intervals (CIs): 0.35–0.70, P
Most cancers eventually metastasize as lymph node metastasis (LNM) and distant metastasis (DM)
Summary
In 2012, nearly 8.2 million people reportedly died from cancer and about 14.1 million people were diagnosed with cancer worldwide [1]. Long noncoding RNA (lncRNA) are transcribed RNA molecules that lack an open reading frame and are longer than 200 nucleotides [3]. They are involved in epigenetic regulation, transcriptional and posttranscriptional regulation that are key cellular processes that determine tumorigenesis [4]. Dysregulation of lncRNAs has been reported in many types of cancers [5,6,7,8] Since they have been implicated in different stages of cancer progression including proliferation, invasion and metastasis, they are promising prognostic markers for cancer [9,10, 11]. Identification of tumor related lncRNAs that are vital in tumorigenesis are promising biomarkers for cancer prognosis
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