Abstract
Background: Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results. This meta-analysis synthesized existing data to clarify the association between FTX with cancer prognosis.Methods: PubMed, Embase, Cochrane library, Web of Science, Chinese CNKI, and the Chinese WanFang databases were used to search for relevant studies. The role of FTX in cancers was evaluated by pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs).Results: Eleven studies comprising 1210 participants including colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastric cancer (GC), renal cell carcinoma (RCC), osteosarcoma (OSC), and glioma were enrolled in this analysis. The meta-analysis showed that high FTX expression was significantly associated with several clinicopathological characteristics, including lymph node metastasis in patients with CRC, GC, HCC, and RCC, distant metastasis in patients with CRC, GC, HCC, and OSC, larger tumor size in patients with CRC, GC, HCC, RCC, and OSC, and subsequently TNM/clinical stage in patients with CRC, GC, HCC, OSC, and glioma. The pooled results from the survival analysis revealed a significant correlation between high FTX expression and shorter OS in patients with HCC, CRC, GC, OSC, and glioma. Further, FTX overexpression could be an independent predictive marker for shorter OS in patients with CRC, HCC, OSC, and glioma.Conclusions: FTX may be a potential oncogene, with high FTX expression being associated with a poorer prognosis in patients with CRC, HCC, OSC, and glioma.
Highlights
Received: 18 November 2020Revised: 21 December 2020Accepted: 04 January 2021Accepted Manuscript online: Version of Record published: The latest cancer statistics indicate that cancer is the leading cause of human death both in the world and in China [1,2], which results in serious economic burden
Studies that met the following criteria were included in the analysis: (1) the expression of five prime to Xist (FTX) in patients with cancers was examined in tumor tissues and assessed using qRT-PCR; (2) the results provided survival information including overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and recurrence-free survival (RFS); (3) hazard ratios (HRs) for survival outcomes were provided or could be calculated from survival curves; and (4) the most recent paper was selected in cases of a repeat study
The pooled HRs for OS was extracted from eight heterogeneous studies (I 2 = 68.3%, P=0.002) comprising 937 patients, and the results showed a significant correlation between high FTX expression and a shorter OS
Summary
Received: 18 November 2020Revised: 21 December 2020Accepted: 04 January 2021Accepted Manuscript online: Version of Record published: The latest cancer statistics indicate that cancer is the leading cause of human death both in the world and in China [1,2], which results in serious economic burden. Many patients are at an advanced stage of cancer at the time of diagnosis, which leads to a poor prognosis. LncRNAs were previously misunderstood as being the noise of genome transcription with no biological function [4]. A large number of lncRNAs are associated with various types of cancer, which may exhibit tumor-suppressive and promoting (oncogenic) functions, License 4.0 (CC BY). Several studies have assessed the relationship between long non-coding RNA five prime to Xist (FTX) expression, clinicopathological features, and survival outcomes in patients with cancer with conflicting results. This meta-analysis synthesized existing data to clarify the association between FTX with cancer prognosis
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