Abstract
In recent years, diabetes mellitus has become a global issue with increasing incidence rate worldwide. Diabetic cardiomyopathy (DCM), one of the important complications of diabetes, refers to patients with type 1 and type 2 diabetes who have ventricular hypertrophy, fibrosis and even diastolic dysfunction. The pathogenesis of DCM is related to oxidative stress, inflammatory response, apoptosis, autophagy, myocardial fibrosis and, diabetic microangiopathy. Long non-coding RNAs (lncRNA) is a non-coding RNA with a length longer than 200 nucleotides which lack the ability of protein coding. With the development of molecular technology, massive evidence demonstrates that lncRNA play a critical role in the molecular mechanism of DCM. Moreover, it can also be used as potential diagnostic markers for DCM. In this review, we intend to summarize the pathological roles and molecular mechanism of lncRNA in the progression of diabetic cardiomyopathy, which may provide promising diagnosis and treatment strategies for DCM.
Highlights
Diabetes mellitus (DM) is a metabolic syndrome characterized by a high glucose level caused by decreased insulin level or insulin insensitivity
We summarize the recent progresses about the involvement of Long non-coding RNAs (lncRNA) in the development of diabetic cardiomyopathy
We show a number of lncRNAs are responsible for the regulation of myocardial fibrosis, cardiomyocyte hypertrophy, oxidative stress, inflammatory response, apoptosis, and autophagy, which are important mechanisms associated with Diabetic cardiomyopathy (DCM) (Table 1)
Summary
Diabetes mellitus (DM) is a metabolic syndrome characterized by a high glucose level caused by decreased insulin level or insulin insensitivity. The mechanism for the development and progression of DCM is complicated, and local inflammation, mitochondrial dysfunction, oxidative stress, apoptosis, autophagy, and metabolic disturbance have been identified to play a role [4]. Long non-coding RNAs (lncRNAs) are a large cluster of non-protein-coding RNAs longer than 200 nucleotides, but they have the ability to control gene expression in epigenetic, transcriptional, and post-transcriptional levels [5]. It is well-established that lncRNAs participate in various biological processes, including cell proliferation and migration, differentiation, inflammation, apoptosis and autophagy [6]. We summarized the relationship between DCM and lncRNAs to further uncover the important roles of lncRNA in the pathogenesis of DCM, and we provided a new perspective about targeting lncRNA as a new therapeutic strategy for a better management of patients with DCM
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