Abstract
Hypertrophic cardiomyopathy (HCM) represents one of the most common heritable heart diseases. However, the signalling pathways and regulatory networks underlying the pathogenesis of HCM remain largely unknown. Here, we present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors. This dataset constitutes a valuable resource for the community to examine the dysregulated coding and lncRNA genes in HCM versus normal conditions.
Highlights
Background & SummaryHypertrophic cardiomyopathy (HCM) represents one of the most common heart diseases, and a leading cause of sudden death in young people[1,2]
HCM is generally regarded as a genetic disorder caused predominately by mutations in eight sarcomere genes, including MYH7, MYBPC3, ACTC1, TPM1, MYL2, MYL3, TNNI3, and TNNT23
There is increasing evidence showing that Long non-coding RNAs (lncRNAs) are involved in a variety of biological processes and diseases5,6. lncRNAs have been implicated in pathologically processes of HCM, such as cardiomyocyte disarrangement, myocardial hypertrophy and interstitial fibrosis[7]
Summary
Background & SummaryHypertrophic cardiomyopathy (HCM) represents one of the most common heart diseases (an estimated prevalence of at least 0.2%), and a leading cause of sudden death in young people[1,2]. We still lack a strand-specific RNA-seq dataset for myocardial tissues of HCM patients. We present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors.
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