Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection

Shuyi Wu,Shuyi Wu,Bingna Zheng,Jianmeng Xu,Jianmeng Xu,Shulu Luo,Shulu Luo,Dingcai Wu,Run Yao,Run Yao,Leiyan Zou,Leiyan Zou,Yan Li,Yan Li,Guobin Liang,Guobin Liang

doi:10.1038/s41467-021-23069-0

Shuyi Wu, Shuyi Wu + Show 14 more

Open Access

https://doi.org/10.1038/s41467-021-23069-0

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Journal: Nature Communications	Publication Date: Jun 3, 2021
Citations: 128	License type: open-access

Affiliation: Stomatology Hospital, Sun Yat-sen University

Abstract

Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection.

Highlights

Peri-implant infection is one of the biggest threats to the success of dental implant
Surface pore-making via alkali-heat treatment provides the titanium surface with well-developed porosity and high surface area so as to graft as many N-halamine polymeric chains as possible during the subsequent surface grafting of polyacrylic acid (PAA)
For N-Cl functionalization, Ti-PAA is reacted with excess ethanediamine and sodium hypochlorite (NaOCl), which yields the aminated sample Ti-PAA-NH and the targeted product Ti-PAA-NCl with the porous N-halamine polymeric coating, respectively

Summary

Introduction

Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. We report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface After consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection. The complex surface characteristics of dental implants, irregular bone defect morphology and limited therapeutic approaches tend to decrease the effectiveness of mechanical debridement, and the recurrent use of antibiotics increases the risk of bacterial resistance[19]

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