Abstract
AbstractOver the past more than ten years, my laboratory has been engaged in the total synthesis, medicinal chemistry, and chemical biology studies on daptomycin. Our efforts are expected to advance new understanding of this effective cyclic lipodepsipeptide antibiotic. In this Account, this long journey is presented.1 Introduction2 Total Synthesis of Daptomycin3 Medicinal Chemistry of Daptomycin4 Molecular Comparison of Daptomycin and Kynomycin5 New Insight into How Daptomycin Exerts Bactericidal Effect6 Conclusion
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