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Abstract
Male Wistar rats were treated daily and intraperitoneally with CdS-Dextrin nanoparticles (100 μg/kg) during 30, 60, and 90 days. The effect of subacute and chronic administration of CdS-Dextrin nanoparticles on CD4/CD8 subpopulations of thymocytes, spleen-derived T cells, and peripheral blood CD4/CD8/CD3 T cells were analyzed by flow cytometer using a Rat T Lymphocyte Cocktail.
Highlights
Advances in nanotechnology have increased the number of toxicological studies meant to understand and predict the effect nanomaterials have in human beings [1,2,3]
Our results indicate that CdS-Dextrin nanoparticles interact with secondary lymphoid organs, modifying cell populations and the levels of soluble mediators in the immune system
The spleen showed a significant increase of CD4+ T cells (13.7%) in the group treated with CdS-Dextrin nanoparticles for 60 days (p
Summary
Advances in nanotechnology have increased the number of toxicological studies meant to understand and predict the effect nanomaterials have in human beings [1,2,3]. Several studies have shown that, when they come into contact with human cell lines or animal tissue, nanomaterials induce different responses that are basically dependent on their physicochemical and optical properties, as well as the biological environment. These studies serve to lay the foundations for the secure use of nanomaterials [4,5,6,7,8]. The efficacy of a nanomaterial can be affected depending on whether a reaction in the organism triggers an acute innate immune inflammatory reaction, chronic inflammation, etc. [9,10,11,12]
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