Abstract
The ability for ultrasound to enhance drug delivery through the skin has been established in an animal model. This research tested the delivery of a therapeutic agent into human skin using sustained ultrasonic application over multiple hours. An IRB-approved pilot study was conducted using hyalaronan, a polymer found in the skin and associated with hydration. To assess the effectiveness of the delivery, a standard protocol was applied to measure moisture of the volar forearm with a corneometer. Fifteen subjects applied the hyalaronan to their forearms daily. One location was then treated with a multi-hour ultrasonic treatment, and the other was not. Baseline skin hydration measurements were taken for one week, followed by daily treatments with moisturizer and corneometer measurements twice per week for three weeks. Subjects experienced double the increase in sustained moisture when ultrasound was used in conjunction with a moisturizer when compared to moisturizer alone (p<0.001) over the four weeks. This study successfully demonstrated ultrasound treatment enhanced delivery of a therapeutic agent into the skin.
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