Abstract
AbstractWe synthesized Fe(II)‐based metallo‐supramolecular oligomers with the different degree of polymerization (DP) (DP‐1, −5 and −10) by changing the molar ratio of Fe(II) acetate and bis(terpyridyl)benzene to 1:2, 5:6, and 10:11, respectively. We investigated the chain length effects on the binding affinity to DNA and cytotoxicity to cancer cells in the oligomers. DP‐10 showed five‐time larger DNA binding constant and four‐time stronger cytotoxicity than DP‐1. We also studied the cell apoptosis assay using annexin V‐FITC/PI staining by flow cytometry and revealed that the ratio of early and late apoptosis cells increased from 15.6% (DP‐1) to 61.4% (DP‐10) with increasing the chain length.
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