Abstract
This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.
Highlights
Excess accumulation of body fat mass resulting from unhealthy dietary patterns and lifestyles directly induces obesity
Among the complex factors affecting the progression of obesity, the gut microbiota plays an important role in host nutrient digestion and energy metabolism [3]
high fat diet (HFD) induced a remarkable increase in epididymal adipose size, while SC-LCBs feeding dramatically inhibited the increase by 66.09% (p < 0.01) (Figure 2)
Summary
Excess accumulation of body fat mass resulting from unhealthy dietary patterns and lifestyles directly induces obesity. The high incidence of obesity leads to a series of public health problems and increases the risks of various diseases, including type 2 diabetes, fatty liver, hyperlipemia, atherosclerosis, cardiovascular disease, and even cancer [2]. Among the complex factors affecting the progression of obesity, the gut microbiota plays an important role in host nutrient digestion and energy metabolism [3]. Accumulating data support the idea that the gut microbiota represents a novel way for the control of obesity and its related diseases [4,5,6]. The increase in Firmicutes, and the reductions in Bacteroidetes, Desulfovibro, and Bifidobacterium (obesity-related bacteria) positively lead to the development of obesity in human and rodents [7,8], but such clinical studies reported that there may be no significant association between obesity and the abundances of Firmicutes and Bacteroidetes [9,10], implying that obesity can be affected by other factors.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
