Abstract
Abstract This experimental study concerns HPSEC data obtained with narrow and broad molecular weight distribution (MWD) samples of poly (styrene) and poly (methylmethacrylate) (PMMA). Using an internal standard approach for adjusting flow rate variations, the variance components of within-a-day and between-day precision are estimated over a period of ten months. It is demonstrated that, by using an internal standard, fundamental assumptions of linear regression theory are satisfied. Long term estimates of precision for MD, Mw, Mz and the polydispersity ratio, Mw/Mn, are also derived. It is shown that MWD curves of PMMA generated over a two-year period can, within experimental error, be superimposed even with instrument and column changes. The practical use of statistical regression theory for HPSEC calibration is critically examined.
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