Abstract
The present study was conducted to develop a novel Lomefloxacin-loaded SLN gel to treat eye infections. Lomefloxacin-loaded solid lipid nanoparticles were prepared by the emulsification solvent evaporation method. Stearic acid was used as solid lipid and poloxamer 188 as surfactant. Optimization of nanoformulation was done by Box Behnken Design using Design Expert Software 12. Stearic acid, poloxamer 188 and propylene glycol concentrations were the independent variables and particle size and % entrapment efficiency (EE) were dependent variables. The optimized lomefloxacin-loaded SLN was further incorporated into Chitosan (LSNG). A total of 9 batches (LSNG1 to LSNG9) were prepared by varying the concentration of Chitosan from 0.05% w/v to 0.25%w/v. LSNG8 was selected as an optimized batch based on its gelling capacity and viscosity. In vitro and ex vivo studies of LSNG8 showed drug release for a prolonged period of time. Furthermore, the HET-CAM test revealed that the formulation is non-irritant and thus can be well tolerated when instilled in the eye. Therefore, LSNG8 can offer improved management of microbial growth.
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