Abstract
Among primary progressive aphasias (PPAs), logopenic variant PPA (lv-PPA) is usually related to Alzheimer's disease. Although it has been widely clinically and pathologically evaluated, the topography in LPA is still controversial. We report a patient presenting with a logopenic syndrome due to a strategic lesion located in the superior and middle temporal gyrus and compare our findings with those of a PiB-PET positive lv-PPA patient matched by age, gender, and education. We consider that our study provides new anatomical clues to better understand the cognitive mechanisms underlying the logopenic syndrome.
Highlights
Primary progressive aphasia (PPA) refers to a clinically and pathologically heterogeneous group of neurodegenerative disorders characterized by progressive language difficulty with relative sparing of memory and other cognitive functions, at least early in the disease course [1]
Based on the clinical profile, progressive aphasias (PPAs) are divided into three different variants: i) semantic variant PPA, ii) non fluent variant PPA, and iii) logopenic variant PPA. sv-PPA and nfv-PPA are usually related to frontotemporal lobar degeneration, while lv-PPA is commonly associated with Alzheimer’s disease (AD) [2]
We report a patient presenting with a logopenic syndrome due to a strategic lesion located in the superior and middle temporal gyrus and compare our findings with those of a 11CPittsburgh compound B PET (PiB-PET) positive lv-PPA patient matched by age, gender, and education
Summary
Primary progressive aphasia (PPA) refers to a clinically and pathologically heterogeneous group of neurodegenerative disorders characterized by progressive language difficulty with relative sparing of memory and other cognitive functions, at least early in the disease course [1]. Comprehension, grammatism, and language articulation are usually less affected [1]. It has been widely pathologically evaluated, the topography in lv-PPA is still controversial. Many authors have described infarcts causing amnesticmultidomain cognitive deficits, as well as other aphasic syndromes [6, 7]; the association of a strategic stroke mimicking a lv-PPA syndrome has not been reported to our knowledge. We consider that our study provides new anatomical clues to better understand the cognitive mechanisms underlying the logopenic syndrome
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