Abstract
The “Landscape Of Gut Microbiome - Pan-India Exploration”, or LogMPIE study, is the first large-scale, nationwide record of the Indian gut microbiome. The primary objective of the study was to identify and map the Indian gut microbiome baseline. This observational study was conducted across 14 geographical locations in India. Enrolled subjects were uniformly distributed across geographies (north, east, west and south) and body mass index (obese and non-obese). Furthermore, factors influencing the microbiome, such as age and physical activity, were also considered in the study design. The LogMPIE study recorded data from 1004 eligible subjects and reported 993 unique microorganisms across the Indian microbiome diaspora. The data not only map the Indian gut microbiome baseline but also function as a useful resource to study, analyse and identify signatures characterizing the physiological dispositions of the subjects. Furthermore, they provide insight into the unique features describing the Indian microbiome. The data are open and may be accessed from the European Nucleotide Archive (ENA) portal of the European Bioinformatics Institute (https://www.ebi.ac.uk/ena/data/view/PRJEB25642).
Highlights
Background & SummaryThe gut microbiome and its host share a primarily symbiotic, commensal relationship that is occasionally pathogenic[1]
An increasing body of evidence substantiates that the gut microbiome plays a critical role in digestion, nutrition, and immune system maturation[2,3,4,5,6,7]
With advancements in the gut microbiome field, modulation of host physiology and biochemistry by the microbiome is being investigated in greater detail[16]
Summary
Background & SummaryThe gut microbiome and its host share a primarily symbiotic, commensal relationship that is occasionally pathogenic[1]. With advancements in the gut microbiome field, modulation of host physiology and biochemistry by the microbiome is being investigated in greater detail[16]. To better understand host physiology modulation by the gut microbiome, it is imperative to know the microbiome composition. Acknowledging this requirement, multiple consortia were set up to map the gut microbiome across different geographies. Multiple nationwide and cohort-specific studies were conducted to understand the impact of the gut microbiome. These studies led to an exponential rise in available gut microbiome datasets across multiple cohorts
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