Logistic regression analysis of cervical lymph node jumping metastasis factors in papillary thyroid carcinoma

Abstract

Objective To explore the related risk factors of cervical lymph node jumping metastasis in papillary thyroid carcinoma. Methods A total of 161 patients with thyroid cancer who underwent thyroidectomy in our hospital from June 2013 to January 2018 were collected and divided into two groups according to the occurrence of lymph node jumping metastasis, the clinical data were analyzed by SPSS 24.2 software. The data of class and geometric data were statistically described by frequency and constituent ratio, and compared by chi square test. Logistic regression analysis was used to analyze significant variables in univariate analysis. In this study, the difference in P<0.05 was statistically significant. Results A total of 25 cases of 161 patients had lymph node jumping metastasis and the incidence of lymph node jumping metastasis was 15.5%. Univariate analysis showed that age, tumor size and tumor location were closely related to the incidence of skip metastasis (P<0.05). Multivariate analysis showed that the primary tumor less than 1 cm (OR=0.182, 95%CI=0.070~0.472, P=0.000) and the tumor located at the upper pole of the thyroid gland (OR=0.218, 95%CI=0.082~0.574, P=0.002)was an independent risk factor of skipping cervical lateral lymph node metastasis. Conclusion The location of the tumor in the upper pole and ≤1 cm are closely related to the jumping metastasis in patients with papillary thyroid carcinoma. For these patients, lateral neck lymph node dissection is recommend to reduce the recurrence risk of clinical papillary thyroid carcinoma when necessary. Key words: Thyroid neoplasms; Adenocarcinoma, papillary; Lymphatic metastasis; Risk factors