Abstract
The various complications related to diabetes are due to the alteration in plasma components and functional activity of blood cells, hence the search for preventive remedies that would ameliorate the clinical condition of patients is a relevant problem today. The main aim of the present study was to examine the antidiabetic potency and antioxidant effects of loganic acid (LA) in blood of diabetic rats. LA showed a restoration of balance between functioning of antioxidant defense system and oxidative stress in leukocytes without notable effects on blood glucose levels when administered orally to rats (20 mg/kg b.w./day) for 14 days. LA ameliorated antioxidant status in leukocytes, as indicated by increasing the content of reduced glutathione and activities of catalase, glutathione peroxidase and glutathione reductase along with decreasing levels of intracellular reactive oxygen species. In addition, we observed the ability of LA to protect against formation and accumulation of glycation and oxidation protein products and malondialdehyde derivates in plasma. Therefore, LA showed antioxidant properties that may have beneficial effects under diabetes. Such results may represent LA as one of the plant components in the development of new drugs that will correct metabolic and functional disorders in leukocytes under diabetes.
Highlights
Diabetes mellitus (DM) is one of the most common endocrine diseases that have been identified as one of the priority issues for national health systems around the world
We investigated blood parameters (number of erythrocytes and leukocytes, differential leukocyte count, hemoglobin content, mean cell hemoglobin (MHC), erythrocyte resistance to acid hemolysis), parameters associated with carbonyl/oxidative stress (levels of reactive oxygen species (ROS), reduced glutathione (GSH), thiobarbituric acid reactive substances (TBA-RS), Oxidatively Modified Proteins (OMPs), advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs)) and activity of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR)) in leukocytes of rats with streptozotocin-induced DM
We provide evidence that loganic acid (LA), an iridoid glycoside extracted from Cornus mas L. fruits, exhibits antioxidant properties in relation to STZ-induced DM
Summary
Diabetes mellitus (DM) is one of the most common endocrine diseases that have been identified as one of the priority issues for national health systems around the world. The social significance of this problem is due to the fact that DM is associated with development of numerous concomitant diseases, early disability, and metabolic complications [1]. The various complications related to diabetes are determined by changes of blood components. Life 2020, 10, 349 in patients with diabetes [1,2]. Hyperglycemia, which occurs in type 1 DM, induces an increased formation of free radicals, especially superoxide anion radicals.
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