Abstract

The adjacent-categories, continuation-ratio and proportional odds logit-link regression models provide useful extensions of the multinomial logistic model to ordinal response data. We propose fitting these models with a logarithmic link to allow estimation of different forms of the risk ratio. Each of the resulting ordinal response log-link models is a constrained version of the log multinomial model, the log-link counterpart of the multinomial logistic model. These models can be estimated using software that allows the user to specify the log likelihood as the objective function to be maximized and to impose constraints on the parameter estimates. In example data with a dichotomous covariate, the unconstrained models produced valid coefficient estimates and standard errors, and the constrained models produced plausible results. Models with a single continuous covariate performed well in data simulations, with low bias and mean squared error on average and appropriate confidence interval coverage in admissible solutions. In an application to real data, practical aspects of the fitting of the models are investigated. We conclude that it is feasible to obtain adjusted estimates of the risk ratio for ordinal outcome data.

Highlights

  • Several logit-link regression models have been proposed to deal with ordered categorical response data

  • The purpose of this paper is to investigate the practicality of fitting the ordinal models with a logarithmic link in place of the logit link

  • We refer to the resulting models as the adjacent categories (AC) probability model, the continuation-ratio (CR) probability model, and the proportional probability (PP) model

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Summary

Introduction

Several logit-link regression models have been proposed to deal with ordered categorical response data. Three of these are the adjacent categories model [1], the continuation-ratio model [2], and the cumulative odds model [3]. The purpose of this paper is to investigate the practicality of fitting the ordinal models with a logarithmic link in place of the logit link. We refer to the resulting models as the adjacent categories (AC) probability model, the continuation-ratio (CR) probability model, and the proportional probability (PP) model. The ordinal log-link models make it possible to directly estimate different but related forms of the risk ratio in prospective studies and the prevalence ratio in cross-sectional studies, overcoming thereby a limitation of logit-link models.

Log Multinomial Model
Forwards-Descending AC Probability Model
Assessment of Loss of Model Fit
Forwards-Descending Conditional Model
Forwards-Descending CR Probability Model
Forwards-Descending Cumulative Probability Model
Forwards-Descending PP Model
Three Properties of a Fully-Constrained Cumulative Probability Model
Starting Values
Non-Admissable Solutions
Non-Convergence
Simulation Study
Application to Real Data
Discussion
Findings
Conclusion
Full Text
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