Lofgren syndrome: Not an uncommon entity

Abstract

Lofgren syndrome is a rare acute phenotypic variant of sarcoidosis characterized by short febrile illness associated with symptoms triad of polyarthritis, hilar adenopathy, and erythema nodosum (EN). We describe a patient who presented with migratory polyarthritis, bilateral acute anterior granulomatous uveitis, and EN on both legs. Chest imaging showed bilateral enlarged multiple mediastinal lymph nodes and paratracheal lymph nodes. Transbronchial lung biopsy revealed noncaseating granulomas. He was successfully treated with prednisolone and methotrexate. Prompt recognition of such classical clinical presentation of sarcoidosis leads to early diagnosis and treatment.