LOEWE Workshop Particle Characterization in Medicine and Biology

Mukul Ashtikar ,Karsten Mäder ,Martin Klein ,Katrin Wunderlich ,Pierre-Yves Lozach ,Fiona Gao ,Stefan Mende ,Claire Strasser ,Tom Dennison ,Marco Marenchino ,Matthias G Wacker

doi:10.20900/pf20190002

Abstract

The workshop “Particle Characterization in Medicine and Biology” jointly organized by the LOEWE research center for Translational Medicine and Pharmacology and Malvern Panalytical Ltd. was held at the University Hospital, Goethe University in Frankfurt/Main on September 20th 2018. Speakers from academia and industry gave insights into particle manufacture and characterization in various environments. Further, the implications for drug delivery and clinical translation of micro and nanotherapeutics were discussed.

Highlights

The workshop Particle Characterization in Medicine and Biology of the LOEWE research center for Translational Medicine and Pharmacology was held in University Hospital, Goethe University, Frankfurt/Main on September 20th 2018 and was cosponsored by the House of Pharma e.V. and Malvern Panalytical Ltd
In the third case study, he introduced the audience to a novel technique for measuring the drug release from nanoparticle formulations which was developed at the Goethe University [4] and is commercialized in collaboration with Pharma Test Apparatebau AG
Particle size distributions generated using dynamic light scattering and Nanoparticle Tracking Analysis (NTA) for 10% fetal bovine serum (FBS) diluted in ultrapure water show a high concentration of particles present throughout 1 to 1000 nm range

Summary

Introduction

The workshop Particle Characterization in Medicine and Biology of the LOEWE research center for Translational Medicine and Pharmacology was held in University Hospital, Goethe University, Frankfurt/Main on September 20th 2018 and was cosponsored by the House of Pharma e.V. and Malvern Panalytical Ltd.Attendees of the workshop were introduced to a wide range of applications, where particle characterization plays a dominant role for the translation of nanotechnologies from bench to bedside. After explaining the use of nanotechnology for drug delivery, he presented the example of iron oxide particles which exhibit a significant variability in particle size when measured by dynamic light scattering Matthias highlighted the need for combining different techniques and reporting the conditions under which particle size is measured to obtain reliable results.

Results

Conclusion