Abstract
A cancer angiogenesias is a complex system. Its robustness is supported by the signaling elements from cancer hypoxic microenvironment. The signaling angiogenic networks have nodal organization of its elements. The AKT is crucial macromolecule in the nodal angiogenic system of solid cancers, leukemia, lymphoma, plasmocytoma and myeloma. Targeting AKT locus by the locus chemotherapy, angiogenesis and all cancer system will fail. The AKT dephosphorylation phenomenon is induced by the redox balance change, causing conversion of the positive loops into normal feedback loops and leading to abolishment of cancer angiogenesis and cancer progression.
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