Locus ceruleus and immunity. III. Compromised immune function (antibody production, hypersensitivity skin reactions and experimental allergic encephalomyelitis) in rats with lesioned locus ceruleus is restored by magnetic fields applied to the brain.

Abstract

This study deals with the relationship between the immunosuppression induced by electrolytic lesions placed into the nucleus locus cerules and the immunopotentiation produced by micromagnets implanted to the parietal area of the skull. The following groups of rats were set up: LC, rats with lesioned locus ceruleus; ShL, sham-lesioned animals bearing non-magnetic beads in the brain parietal region; M, rats with micromagnets of 60 mT influx density in the parietal part of the skull; LCM, animals with impaired locus ceruleus and magnetic beads placed in the parietal area of the skull; and IC, intact control rats. Animals of all groups were tested for plaque-forming cell response, circulating antibodies to sheep red blood cells and bovine serum albumin, Arthus and delayed hypersensitivity skin reactions to bovine serum albumin and old tuberculin, and experimental allergic encephalomyelitis. In LC-rats, humoral and cell-mediated immune reactions were compromised. On the other hand, immune responses in M-rats were significantly potentiated. In LCM-rats, however, the immunosuppression induced by destruction of the locus ceruleus was abrogated by prolonged exposure of the brain parietal region to the magnetic fields, i.e. immune reactivity of LCM-rats was quite similar to that of control IC- and ShL-animals. Several mechanisms may account for the immunomodulating effects produced by lesioning of the locus ceruleus and exposure of the brain to magnetic fields. Noradrenergic, serotoninergic, dopaminergic and peptidergic neurotransmitters, as well as growth hormones and immunopeptides, produced within the central nervous system or elsewhere, may be implicated as necessary for the interactions among the brain, immune apparatus and magnetic fields.