Abstract
Amygdala-kindled rats and handled controls were tested for differences in locomotion and convulsive activity produced by picrotoxin, a specific synaptic antagonist of the putative neurotransmitter GABA. Compared with controls, the gross activity of kindled rats decreased more rapidly with dose (0.5 to 2.0 mg/kg, i.p.) and kindled rats were more likely to convulse with the higher doses (1.0 to 2.0 mg/kg). These results suggest a functional deficit in the GABA system of kindled rats as measured by locomotion and convulsive activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
