Abstract
IN eukaryote cells chromosomal proteins are responsible for the organisational state of the DNA and the control of genetic expression, therefore knowledge of their location is an essential prerequisite for understanding chromosome function. Cytological localisation of chromosomal proteins is feasible using cells with giant chromosomes such as the oocytes of the newt Triturus cristatus carnifex where there are clearly defined regions active in RNA transcription (the loops) and regions containing most (>95%) of the DNA in a condensed state (the chromomeres)1. There are two main classes of protein associated with chromosomes: histones, which are generally considered to be complexed with the sugar-phosphate backbone of the DNA2; and nonbasic proteins which are constituents of metabolically active chromatin3.
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