Abstract
Purpose: Preventing disease development and/or progression of osteoarthritis of the knee (KOA) has been sought from standpoint of not only social welfare but also social economy. Due to rapid progression of aging society the requirement is growing worldwide. Unfortunately effective method is still open to be explored and researchers are straggling to establish it. One possible first step is to achieve this will be to detect initial change of KOA as early as possible. Imaging biomarkers are thought to be suitable for this purpose due to its property to assess only corresponding joint without being affected by systemic changes.
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