Locally Delivered Doxycycline has no Long-Term Benefits for Periodontal Health

Abstract

Article Title and Bibliographic Information Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. Bogren A, Teles RP, Torresyap G, Haffajee AD, Socransky SS, Wennstrom JL. J Periodontol 2008;79(5):827-35. Reviewer Francis G. Serio, DMD, MS, MBA Purpose/Question The authors studied the long-term clinical and microbiological effects (3 years) of yearly applications of locally delivered doxycycline as an adjunct to mechanical supportive periodontal therapy (SPT) compared with conventional SPT without locally delivered antibiotic. Source of Funding Government - National Institute of Dental and Craniofacial Research (USA) Type of Study/Design Multicenter, randomized controlled clinical trial with calibrated and blinded examiners. Level of Evidence Level 1: Good-quality, patient-oriented evidence Strength of Recommendation Grade Grade A: Consistent, high-quality patient-oriented evidence