Abstract
Localized Management of Soft Tissue Sarcoma Metastasis: A Review of a Multidisciplinary Approach.
Highlights
Soft tissue sarcomas (STS) are a rare malignancy that has unpredictable clinical and pathologic behaviors
Canter et al, showed that the median post-metastasis disease-specific survival rates in patients with pulmonary-only metastases were lower for those that were administered chemotherapy compared to those that were treated with surgery alone, 24 vs 33 months [25]
Studies have demonstrated that patients with limited burden pulmonary disease (≤5 pulmonary metastases) have higher median metastatic survival of up to 55 months [7]
Summary
Soft tissue sarcomas (STS) are a rare malignancy that has unpredictable clinical and pathologic behaviors. Despite excellent rates of local control with surgery, radiation and chemotherapy, metastasis develops in approximately 25-30% of patients [1,2,3,4,5]. STS metastasis most commonly spreads to the lungs, other areas of distant disease, such as soft tissue, bone, and visceral organs have been identified [6]. The metastatic potential for primary STS may be a result of various factors, and identifying these factors that influence metastatic survival is crucial if sarcoma specialists are to be able to discuss treatment options and prognosis with their patients. The mainstay of therapy for disseminated metastatic STS is chemotherapy. There has been an evolution in this patient population toward the utilization of less invasive treatment modalities such as radiation and percutaneous ablative techniques to treat metastatic lesions [8,9,10,11,12]
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