Abstract
Ewing sarcoma (ES) is a high-grade malignant primary round cell tumour of bone in which there is commonly extension into extraosseous soft tissues at the time of diagnosis. This report details the clinical, radiological and pathological features of a case of ES of the tibia in which there was extensive osseous involvement but no infiltration beyond the periosteum into surrounding soft tissue. We also record the findings of one other ES case that exhibited similar behaviour. Both cases were male, involved the tibia and had the characteristic t (11;22) (q24;q12) translocation. No recurrence of tumour or metastasis has been seen in these two cases, both of which have had 6 years follow-up. Our findings indicate that there is heterogeneity in the behaviour of ES and show that localized ES is associated with a good prognosis.
Highlights
Ewing sarcoma (ES) is a malignant tumour of bone which is composed of small round tumour cells [1,2]
We describe the findings in one other case of ES of the tibia arising in a male that behaved
The morphological, immunophenotypic and molecular genetic findings indicated this was a case of ES which unusually appeared to be effectively confined to the bone with no periosteal or extraosseous soft tissue involvement
Summary
Ewing sarcoma (ES) is a malignant tumour of bone which is composed of small round tumour cells [1,2]. The tumour commonly involves the diaphysis and metaphysis with the epiphysis affected in only 2% of cases; radiologically, there is extensive permeative or moth eaten bone destruction and a soft tissue mass is seen in approximately 90% of cases at the time of diagnosis [4].
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