Abstract
Growth factors are shown to promote cell proliferation and apoptosis, regulate tissue differentiation, and modulate organogenesis. In the present investigation, the Localization of transforming growth factor s1 (TGF s1) was studied on the testis of brown banded-bamboo shark by immune-histochemistry. The immunehistochemical reaction was present in the somatic cells, mainly Leydig cells, in most of testis zones in summer season, while in winter season the expression was confined to the Leydig cells of the spermatocytes, spermatids and spermatozoal zones. The reaction in the germ cells was clear in the spermatogonia of the germinal zone in the summer season while in winter it was clear in the head of sperms in the spermatozoal zone and negative in other zones in both sea- sons. In conclusion, these results demonstrate seasonal variation in the expression of TGF B 1 in the testes of this shark. This growth factor has a role in the differentiation and migration of spermatogonia, steroidgenesis through its effect on the Leydig cells either stimulating or inhibiting and finally apoptotic effect on either germinal epithelium or Leydig cells.
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