Localization of the Gene Encoding the Secretin Receptor, SCTR, on Human Chromosome 2q14.1 by Fluorescencein SituHybridization and Chromosome Morphometry

Abstract

It has been over 90 years since the discovery of secretin, a duodenal mucosal hormone that stimulates the secretion of bicarbonate, enzymes, and potassium ions by the pancreas. It is now known that secretin is one of the most potent physiological regulators of bicarbonate, water, potassium ion, and enzyme secretion from the pancreas. Other pharmacological actions of secretin have also been reported, with effector tissues throughout the body, including the brain, heart, stomach, intestine, and kidney. The rat secretin is a 27-amino-acid peptide that is synthesized as a precursor protein of 134 amino acids in specific endocrine cells. The nucleotide sequence analysis of the cDNA has revealed that the secretin receptor is a new type of the G protein-coupled receptor with seven transmembrane segments. 9 refs., 1 fig.