Abstract
BackgroundTo investigate the feasibility of indocyanine green (ICG) use in localizing subcentimeter pulmonary nodules during uniportal video-assisted thoracoscopic surgery.MethodsThis study was a retrospective analysis of 32 patients who underwent surgery due to pulmonary nodules using ICG localization from September 2019 to March 2020 in the Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University. Laser positioning and large-aperture spiral CT simulation were performed preoperatively. ICG was injected into the lung (2.5 mg/ml). The clinical characteristics and postoperative indicators were recorded.ResultsA total of 33 subcentimeter pulmonary nodules were successfully localized in 32 patients. Twenty-three patients underwent lobectomy, with an average surgical time of 45.3 min and an average tube retention time of 2 days. Non-small cell lung cancer was confirmed intraoperatively in 9 patients, among whom the longest surgical time was 120 min, and the shortest hospital stay was 7 days. No patient was converted to thoracotomy or developed serious complications.ConclusionsICG imaging is a safe and effective technique for localization of pulmonary nodules. Due to the widespread application of near-infrared devices, fluorescent localization and imaging technology will be more widely used in thoracic surgery.
Highlights
To investigate the feasibility of indocyanine green (ICG) use in localizing subcentimeter pulmonary nodules during uniportal video-assisted thoracoscopic surgery
In recent years, due to the development of instruments and techniques for thoracic surgery, uniportal thoracoscopic surgery has been increasingly used in the diagnosis and treatment of lung and thoracic diseases
ICG has been approved by the U.S Food and Drug Administration (FDA) as a safe imaging agent and has almost no risk of allergic reactions
Summary
To investigate the feasibility of indocyanine green (ICG) use in localizing subcentimeter pulmonary nodules during uniportal video-assisted thoracoscopic surgery. Due to the development of instruments and techniques for thoracic surgery, uniportal thoracoscopic surgery has been increasingly used in the diagnosis and treatment of lung and thoracic diseases. Uniportal thoracoscopic surgery is considered to be a feasible and safe method for the treatment of pulmonary. Indocyanine green (ICG) is a near-infrared fluorescent dye. As a highly sensitive and specific fluorescent imaging method, ICG imaging has been introduced for general use for the diagnosis and treatment of pelvic and abdominal tumors, tumor-node-metastasis, and ocular vascular and neurological diseases [5]. This study aimed to explore the safety and feasibility of an ICG fluorescent imaging system combined with laser positioning and CT simulation in intraoperative localization of subcentimeter pulmonary nodules
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